Home Andrew Huberman Episode
Andrew Huberman · 2022-12-12

Tools for Hormone Optimization in Males | Dr. Kyle Gillett

Tools for Hormone Optimization in Males | Dr. Kyle Gillett

Recommended on this episode

ProductRecommended

Creatine monohydrate

“I take 5 grams a day of creatine monohydrate. I do it for the tissue volumizing effects”
“I take 5 grams a day of creatine monohydrate. I do it for the tissue volumizing effects, so for exercise benefits, but also for the cognitive effects.”— Andrew Huberman
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Tongkat ali (Long Jack)

“I take 400 milligrams of tongkat ali per day... I've been taking it for years. And I rather like that the effects.”
“I take 400 milligrams of tongkat ali per day. I take it early in the day because it has a bit of a stimulant effect”— Andrew Huberman

Also referenced (named, not recommended)

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Betaine

“Some people are nonresponders to creatine, so you can increase that to 10 grams, or you can use its cousin betaine to help with amino acid synthesis”— Kyle Gillett
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L-carnitine

“Usually, I recommend for oral l-carnitine between 1,000 milligrams and up to 4,000 or 5,000 milligrams.”— Kyle Gillett
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Vitamin D3

“Let's briefly mention vitamin D, which is also a hormone. And if you have deficient vitamin D and you replace it, then you will optimize your testosterone.”— Kyle Gillett
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Boron

“if you have a very high SHBG, boron can acutely help lower it usually in a dose of 5 to 12 milligrams per day.”— Kyle Gillett
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Fadogia agrestis

“I've been taking fadogia for some period of time. All my markers and tests indicate that there's no toxicity. But I've been taking 600 milligrams per day”— Andrew Huberman
ProductReferenced

Ibutamoren (MK-677)

“Ibutamoren is a long-acting-- so it has a long half life, also known as MK-677. It was studied mostly in growth hormone deficiency.”— Kyle Gillett
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Tesamorelin

“Tesamorelin is one of them, sermorelin is another one, and CJC is another common one. I believe those are all in the class of GHRH-like peptides”— Kyle Gillett
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BPC-157

“other people, for instance, are taking peptides like BPC 157 to try and improve tissue healing and recovery.”— Andrew Huberman
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Tadalafil (Cialis)

“Tadalafil is a very underrated medication... in general, I recommend no higher than 10 milligrams a day-- usually just two or 5 milligrams.”— Kyle Gillett
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Clomiphene (Clomid)

“The Clomid, or clomiphene, there's two main... diastereomers. And one of them is enclomiphene and one of them is zuclomiphene.”— Kyle Gillett
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Finasteride (Propecia)

“Finasteride inhibits 1 and 2. Dutasteride actually inhibits all three.”— Kyle Gillett
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Dutasteride

“Dutasteride actually inhibits all three. And finasteride inhibits the isoenzyme that is in genital skin”— Kyle Gillett
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Saw palmetto

“saw palmetto is also a 5-alpha reductase inhibitor, but only a couple of the isoenzymes. There's three main isoenzymes”— Andrew Huberman
ProductReferenced

Ketoconazole (topical)

“many people that have just a bit of predisposition, they can use things that are topical anti-androgens. Ketoconazole is one of them, caffeine is actually another one.”— Kyle Gillett